University of Ottawa

Faculty of Medicine

Department of Biochemistry, Microbiology, and Immunology

Roger Guindon Hall
Office: 4232
Labs: 4233, 4248

451 Smyth Road
Ottawa, Ontario
K1H 8M5
Canada

Tel: +1 613 562-5800
Office: Ext. 6374
Labs: Ext. 6371, and 6375
Fax: +1 613 562-5452

altosaar@uottawa.ca

Research

Challenges

Our lab's ongoing research projects are designed to address the following challenges:

  • Atmospheric phytoremediation of nitrous oxide: expression of nitrous oxide reductase from Pseudomonas stutzeri in transgenic plants.
  • Role of tryptophan-rich domains in anti-fungal properties of puroindoline
  • Development of a novel tethering system to improve downstream processing efficiency of plant-derived recombinant protein bioproducts.
  • Newborn Gastrointestinal Tract: Fate of Breast milk-sourced and recombinant soluble CD14

Current Research Topics

To this end, we are currently conducting the following studies.

  • Newborn gastrointestinal tract: Fate of breast milk-sourced and recombinant soluble CD14
  • Atmospheric phytoremediation of nitrous oxide: expression of N2O reductase from Pseudomonas stutzeri in transgenic plants.
  • Role of tryptophan-rich domains in anti-fungal properties of puroindoline
  • Development of a novel tethering systems to improve downstream processing efficiency of plant-derived recombinant protein bioproducts
  • Producing conjugate vaccines without the use of chemicals
  • High throughput screening functional genomic whole-colony method to identify antimicrobial peptides

Collaborators

  • Herbert Kronzucker, U Toronto
  • Stuart Strand, U Washington
  • Xiongying Cheng, Vitegen Inc.
  • Max Hincke, U Ottawa
  • David Mack, CHEO
  • JoAnn Harrold, CHEO