Dr. Odette Laneuville
Associate Professor
Degrees:
B.Sc. (Trois-Rivieres)
M.Sc. (Montreal)
Ph.D. (Toronto)
Contact info:
Roger Guindon Hall, Rm. 4108
Phone: 562-5800 x 8402
Email: olaneuvi@uottawa.ca
Research Interests:
Research in my laboratory aims at understanding the regulation of expression of the enzyme cyclooxygenase. Cyclooxygenase, also named prostaglandin endoperoxide H synthase (PGHS), catalyses the rate limiting step in the synthesis of prostanoids from arachidonic acid. The importance of this enzyme has been revealed by Aspirin and non-steroidal anti-inflammatory agents (NSAIDs) used in a wide variety of clinical contexts for the treatment of pain, fever and inflammation. Aspirin and other NSAIDs inhibit the enzyme PGHS leading to an inhibition in the formation of prostanoids. Three levels of expression of PGHS-1 gene are currently studied in my laboratory. First, regulation at the transcriptional level and regulatory elements in the promoter are identified. Second, regulation at the level of the transcript and RNA processing is studied. And thirdly, regulation at the level protein synthesis and protein stability is studied.
Selected publications:
- N. Bunimov, J.E. Smith, D. Gosselin & O. Laneuville. Translational regulation of PGHS-1 mRNA: 5’ untranslated region and first two exons conferring negative regulation. Biochim. Biophys. Acta 1769(2): 92-105.
- G. Trudel, O. Laneuville & H.K. Uhthoff. Joint contractures.Editorial Comment. Clin. Orthop. Relat. Res. (2007) 456: 2.
- O. Laneuville, J. Zhou, H.K. Uhthoff & G. Trudel. Genetic influences on joint contractures secondary to immobility. Clin. Orthop. Relat. Res.
(2007) 456: 36-41.
- G. Trudel, A. Recklies & O. Laneuville. Increased expression of chitinase 3-like protein 1 secondary to joint immobility. Clin. Orthop.
Relat. Res. (2007) 456: 92-97.
- G. Trudel, H. Uhthoff & O. Laneuville. Prothrombin expression in articular cartilage with a putative role in cartilage degeneration secondary to immobility. J. Rheumatol. (2005) 32(8): 1547-1555.
- G. Trudel, H. Uhthoff & O.Laneuville. Knee joint immobility induces
Mcl-1 gene expression in articular chondrocyte. Biochem. Biophys. Res.
Comm. (2005) 333: 247-252.
- J. Drouin, N. Carson & O. Laneuville. Compound heterozygosity for a novel nine-nucleotide deletion and the Asn45Ser missense mutation in the glycoprotein IX gene in a patient with Bernard-Soulier Syndrome. Am. J.
Hematol. (2005) 78(1): 41-48.
- M. Duquette & O. Laneuville. Translational regulation of prostaglandin endoperoxide H synthase-1 mRNA in the megakaryocytic MEG-01 cells.
Specific binding to a conserved 20-nt cis-element in the 3’-untranslated region.” J. Biol. Chem. (2002) 277(47): 44631-44637.