Susan Nadin-Davis

Adjunct Professor

Department of Biochemistry, Microbiology, and Immunology

Degrees:

B.Sc., University of Cambridge
M.Sc., Dalhousie University
Ph.D., University of Ottawa

Contact info:

Office: CFIA, Ottawa Laboratory (Fallowfield), 3851 Fallowfield Rd, Ottawa, ON K2H 8P9

Phone: (613) 228-6698
Fax: (613) 228-6669
E-mail: Susan.Nadin-davis@inspection.gc.ca

Research Interests:

Application of molecular biology to the development of methods for detection and study of pathogens important to Canadian animal health programmes. In particular Dr. Nadin-Davis has a long-standing collaboration with the Rabies group of CFIA. She has developed extensive expertise in the molecular characterisation of rabies viruses.

Recent projects include:

Use of genetic barcoding to identify rabies positive bats to species
Development of a real-time PCR method to identify Taylorella equigenitalis responsible for cervial equine metritis
Development of molecular methods to discriminate two sub-species of Campylobacter fetus, C. fetus fetus and C. fetus venerealis

Administrative Positions:

2000 – present: Adjunct professor, Department of Biochemistry, Microbiology and Immunology, and member of the school for graduate studies, University of Ottawa.

Select Publications:

Szanto, A.G., Nadin-Davis, S.A., Rosatte, R.C., and White, B.N. Genetic tracking of the raccoon variant of rabies virus in eastern North America. Epidemics, 3: 76-87, 2011.

Szanto, A.G., Nadin-Davis, S.A., Rosatte, R.C., and White, B.N. Re-assessment of direct fluorescent antibody negative brain tissues with a real-time PCR assay to detect the presence of raccoon rabies virus RNA. Journal of Virological Methods, 174: 110-116, 2011.

Nadin-Davis, S.A., Fehlner-Gardiner, C., Sheen, M., and Wandeler, A.I. Characterization of a panel of anti-phosphoprotein monoclonal antibodies generated against the raccoon strain of rabies virus. Virus Research, 152:126-36, 2010.

Nadin-Davis, S.A., Feng, Y., Mousse, D., Wandeler, A.I., and Aris-Brosou, S. Spatial and temporal dynamics of rabies virus variants in big brown bat populations across Canada: footprints of an emerging zoonosis. Molecular Ecology, 19: 2120-36, 2010.

Knowles, M.K., Nadin-Davis, S.A., Sheen, M., Rosatte, R., Mueller, R. and Beresford, A. Safety studies on an adenovirus recombinant vaccine for rabies (AdRG1.3-ONRAB) in target and non-target species. Vaccine, 27: 6619-6626, 2009.

Nadin-Davis, S.A., Sheen, M. and Wandeler, A.I. Development of real-time reverse transcriptase polymerase chain reaction methods for human rabies diagnosis. Journal of Medical Virology, 81:1484-97, 2009.

Knowles, M.K., Roberts, D., Craig, S., Sheen, M., Nadin-Davis, S.A. and Wandeler, A.I. In vitro and in vivo genetic stability studies of a human adenovirus type 5 recombinant rabies glycoprotein vaccine (ONRAB). Vaccine, 27:2662-8, 2009.

Misra, V., Dumonceaux, T., Dubois, J., Willis, C., Nadin-Davis, S., Severini, A., Wandeler, A., Lindsay, R., and Artsob, H. Detection of polyoma and corona viruses in bats of Canada. Journal of General Virology, 90: 2015-22, 2009.
Bielanski, A., Algire, J., Lalonde, A. and Nadin-Davis, S. Transmission of bovine viral diarrhea virus (BVDV) via in vitro-fertilized embryos to recipients, but not to their offspring. Theriogenology, 71: 499-508, 2009.
Szanto, A., Nadin-Davis, S.A. and White, B.N. Complete genome sequence of a raccoon rabies virus isolate. Virus Research, 136: 130-139, 2008.

Johnstone, J., Saxinger, L., McDermid, R., Bagshaw, S., Resch, L., Lee, B., Johnson, M., Joffe, A.M., Benade, G., Johnson, D., Nadin-Davis, S., Cheung, E., Willoughby, R. and Franka, R. Human rabies - Alberta, Canada, 2007. Morbidity and Mortality Weekly Report 57: 197-199, 2008.

Nadin-Davis, S., Muldoon F., Whitney, H., and Wandeler, A.I. Origins of the rabies viruses associated with an outbreak in Newfoundland during 2002-03. Journal of Wildlife Diseases, 44: 86-98, 2008.

Fehlner-Gardiner, C., Nadin-Davis, S., Armstrong, J., Muldoon, F., Bachmann, P., and Wandeler, A. ERA vaccine-derived cases of rabies in wildlife and domestic animals in Ontario, Canada, 1989-2004. Journal of Wildlife Diseases, 44: 71-85, 2008.

Nadin-Davis, S.A., Velez, J., Malaga, C., and Wandeler A.I.. A molecular epidemiological study of rabies in Puerto Rico. Virus Research, 131: 8-15, 2008.

Nielsen, K., Yu, W. L., Lin, M., Nadin Davis, S. A., Elmgren, C., MacKenzie, R., Tanha, J., Li, S., Dubuc, G., Brown, E. G., Keleta, L., and Pasick, J. Prototype Single Step Lateral Flow Technology for Detection of Avian Influenza Virus and Chicken Antibody to Avian Influenza Virus. Journal of Immunoassay and Immunochemistry, 28: 307–318, 2007.

Nadin-Davis, S.A., Turner, G., Paul, J.P.V., Madhusudana, S.N., and Wandeler, A.I. Emergence of Arcticlike rabies lineage in India. Emerging Infectious Diseases, 13: 111-116, 2007.

Nadin-Davis, S.A., Torres, G., de los Angeles Ribas M., Guzman, M., Cruz de la Paz, R., Morales, M. and Wandeler, A.I. A molecular epidemiological study of Rabies in Cuba. Epidemiology and Infection, 134: 1313-1324, 2006.

Nadin-Davis, S.A., Muldoon, F. and Wandeler, A.I. A Molecular Epidemiological Analysis of the Incursion of the Raccoon Strain of Rabies Virus into Canada. Epidemiology and Infection, 134: 534-547, 2006.

Nadin-Davis, S.A. and Loza-Rubio, E. The Molecular Epidemiology of Rabies Associated with Chiropteran Hosts in Mexico. Virus Research, 117: 215-226, 2006.

Nadin-Davis, S.A., Muldoon, F. and Wandeler, A. I. Persistence of genetic variants of the arctic fox strain of Rabies virus in southern Ontario. The Canadian Journal of Veterinary Research 70: 11-19, 2006.
Bernardi, F., Nadin-Davis, S.A., Wandeler, A.I., Armstrong, J., Gomes, A.A.B., Lima, F.S., Nogueira, F.R.B., and Ito, F.H. Antigenic and genetic characterization of rabies viruses isolated from domestic and wild animals of Brazil identifies the hoary fox as a rabies reservoir. Journal of General Virology, 86: 3153-3162, 2005.
Real, L.A., Henderson, J.C., Biek, R., Snaman, J., Lambert Jack, T., Childs, J.E., Stahl, E., Waller, L., Tinline, R., and Nadin-Davis, S. Unifying the Spatial Population Dynamics and Molecular Evolution of Epidemic Rabies Virus. Proceedings of the National Academy of Sciences, USA, 102: 12107-12111, 2005.
Lew, A.E. Bock, R.E., Miles, J., Cuttell, L.B. Steer,P., and Nadin-Davis , S.A. Sensitive and specific detection of bovine immunodeficiency virus and bovine syncytial virus by 5' Taq nuclease assays with fluorescent 3' minor groove binder-DNA probes. Journal of Virological Methods , 116: 1-9, 2004.

Nadin-Davis, S.A. , Abdel-Malik, M., Armstrong, J. and Wandeler, A.I. Lyssavirus P gene characterization provides insights into the phylogeny of the genus and identifies structural similarities and diversity within the encoded phosphoprotein. Virology, 298: 286-305, 2002.

Select Book chapters:

Nadin-Davis S.A., and Real L.A. “Molecular phylogenetics of the lyssaviruses – insights from a coalescent approach.” In A. Jackson, (ed), Advances in Virus Research, vol 79, , Academic Press, pp. 203-238, 2011.

Nadin-Davis, S.A. “Rabies: Virus and Disease.” In Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd: Chichester. DOI:10.1002/9780470015902.a0002244.pub2, December 2010.

Nadin-Davis, S.A. and Fehlner-Gardiner, C. “Lyssaviruses - Current Trends.” In K. Maramorosch, A.J. Shatkin and F.A. Murphy (eds), Advances in Virus Research, vol 71, Academic Press, pp. 207-250, 2008.

Nadin-Davis, S.A. and Bingham, J. “Europe as a source of rabies for the rest of the world.” In A.A. King, A.R. Fooks, M. Aubert and A.I. Wandeler (eds), Historical perspective of Rabies in Europe and the Mediterranean Basin, OIE press, Paris, pp. 259-280, 2004.